Sequential mutations in the NS genes of influenza virus field strains.
Identifieur interne : 002564 ( Main/Exploration ); précédent : 002563; suivant : 002565Sequential mutations in the NS genes of influenza virus field strains.
Auteurs : M. Krystal ; D. Buonagurio ; J F Young ; P. PaleseSource :
- Journal of Virology [ 0022-538X ] ; 1983.
Abstract
The complete nucleotide sequences of the NS genes from three human influenza viruses, A/FM/1/47 (H1N1), A/FW/1/50 (H1N1), and A/USSR/90/77 (H1N1), were determined. Only five single-base differences were found within the sequences of the A/FW/1/50 and A/USSR/90/77 NS genes, thus confirming earlier data suggesting that the 1977 H1N1 viruses are closely related to virus strains that were circulating around 1950. Comparison of all three sequences with those from A/PR/8/34 and A/Udorn/72 viruses illustrates that these genes (with the exception of that of the A/USSR/90/77 strain) evolve through cumulative base changes along a single common lineage. A nucleotide sequence variation of approximately 2.2 to 3.4% per 10 years was determined for the NS gene segments. Extensive size variation was also observed among the NS1 proteins of the various human viruses. The A/FM/1/47 NS1 protein, which consists of 202 amino acids, is 15% shorter than the A/Udorn/72 NS1 protein, which consists of 237 amino acids.
Url:
PubMed: 6834468
PubMed Central: 256448
Affiliations:
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Le document en format XML
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